About teprotumumab
IGF-1 receptor-blocking monoclonal antibody
Used for
- Treats thyroid eye disease in adults, including eye bulging, inflammation, and double vision.
Usual adult dose
10 mg/kg by intravenous infusion initially, then 20 mg/kg every three weeks for seven further infusions.
Common side effects
- Muscle spasms
- Nausea
- Hair loss
- Diarrhea
Important warnings
- May cause hearing impairment, sometimes persistent; assess hearing before, during, and after treatment.
- Can worsen inflammatory bowel disease; monitor for new or worsening symptoms.
- May cause high blood sugar; monitor glucose, especially with diabetes.
- Can harm an unborn baby; use effective contraception during treatment and for six months afterward.
Pregnancy
May cause fetal harm. Avoid during pregnancy; effective contraception is recommended during treatment and for six months after the final infusion.
Breastfeeding
There are no adequate data on presence in human milk or effects on the breastfed child; consider treatment benefits and potential risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.