About tenofovir disoproxil fumarate
Nucleotide reverse transcriptase inhibitor
Used for
- Treats HIV infection with other antiretroviral medicines
- Treats chronic hepatitis B
Usual adult dose
Usually 300 mg once daily for HIV or chronic hepatitis B; dose adjustments may be needed for kidney problems.
Usual dose in children
For HIV, generally 8 mg/kg once daily, maximum 300 mg, for children weighing at least 10 kg; specialist dosing is required.
Common side effects
- Nausea, diarrhea, or headache
- Kidney problems
- Reduced bone mineral density
- Rarely, lactic acidosis or severe liver enlargement
Important warnings
- Kidney function and bone health may need monitoring.
- Do not stop treatment for hepatitis B without medical supervision; liver disease can worsen.
- HIV treatment requires combination medicines; testing for HIV is important before hepatitis B treatment.
- The labeled dose refers to tenofovir disoproxil; product labeling may express tablet content differently.
Pregnancy
Can be used during pregnancy when needed; HIV treatment decisions should involve a clinician.
Breastfeeding
For HIV, breastfeeding is generally discouraged where safe alternatives are available. For hepatitis B, discuss individual risks with a clinician.
Interactions
- Other kidney-harming medicines can increase kidney injury risk.
- Didanosine levels may rise; combined use is generally avoided.
- Some medicines can increase tenofovir levels, requiring monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.