About tenofovir alafenamide
Nucleotide reverse transcriptase inhibitor
Used for
- Treats chronic hepatitis B in adults and children aged 6 years or older, weighing at least 25 kg.
Usual adult dose
25 mg by mouth once daily with food.
Usual dose in children
For ages 6 years or older and weight at least 25 kg: 25 mg by mouth once daily with food.
Common side effects
- Headache
- Abdominal pain
- Nausea
- Fatigue
Important warnings
- Stopping treatment can worsen hepatitis B; liver monitoring may be needed.
- Kidney problems can occur; kidney function should be monitored.
- May cause lactic acidosis or severe liver enlargement with fat, rarely.
- Does not prevent hepatitis B transmission or treat HIV alone.
Pregnancy
Human pregnancy data are limited; discuss use with a healthcare professional. Untreated hepatitis B also carries risks.
Breastfeeding
It is unknown whether tenofovir alafenamide passes into human milk; discuss benefits and risks with a healthcare professional.
Interactions
- Rifampin, rifabutin, and rifapentine can reduce drug levels.
- Carbamazepine, oxcarbazepine, phenobarbital, and phenytoin can reduce drug levels.
- St. John’s wort can reduce drug levels.
- Some HIV medicines require review to prevent duplicate tenofovir treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.