About telotristat ethyl
Tryptophan hydroxylase inhibitor
Used for
- Used with somatostatin analogue therapy for carcinoid syndrome diarrhea inadequately controlled by that therapy.
Usual adult dose
250 mg by mouth three times daily with food.
Common side effects
- Nausea
- Headache
- Constipation
- Abdominal pain
Important warnings
- May cause severe constipation; bowel obstruction has occurred.
- Monitor for worsening abdominal pain, vomiting, or reduced bowel movements.
- Not intended to treat carcinoid syndrome diarrhea alone.
Pregnancy
Human pregnancy data are limited; use only when potential benefit outweighs potential risk.
Breastfeeding
Unknown whether it passes into breast milk; effects on a nursing infant are uncertain.
Interactions
- Strong CYP3A4 inducers can reduce telotristat exposure and effectiveness.
- Telotristat can reduce exposure to CYP3A4 substrates, including midazolam.
- Telotristat can reduce exposure to CYP2B6 substrates, including bupropion.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.