About ceftolozane + tazobactam
Cephalosporin antibiotic plus beta-lactamase inhibitor
Used for
- Complicated urinary tract infections, including kidney infections
- Complicated infections inside the abdomen, with other antibiotics
- Hospital-acquired and ventilator-associated bacterial pneumonia
Usual adult dose
Usually 1.5 g intravenously every 8 hours; pneumonia usually 3 g every 8 hours. Adjust for kidney function.
Usual dose in children
For children 2 years and older: dose is weight-based and depends on infection; specialist prescribing is required.
Common side effects
- Nausea or diarrhea
- Headache or fever
- Anemia or abnormal liver tests
- Infusion-site reactions
Important warnings
- Use only for susceptible bacterial infections; it does not treat viral infections.
- Adjust dose for reduced kidney function; kidney function may change during treatment.
- Serious allergic reactions, severe diarrhea, seizures, or other neurologic effects can occur.
- Use with caution in people with cephalosporin or severe penicillin allergy.
Pregnancy
Human pregnancy data are limited; use when clinically needed after considering potential benefits and risks.
Breastfeeding
It is unknown whether these medicines enter human milk; consider infant monitoring for diarrhea or thrush.
Interactions
- Probenecid may increase exposure to tazobactam.
- Tell clinicians about other medicines, especially those affecting kidney function.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.