About sulphasal azine
Aminosalicylate and sulfonamide anti-inflammatory
Used for
- Ulcerative colitis, including maintenance of remission
- Rheumatoid arthritis
- Juvenile idiopathic arthritis
Usual adult dose
Ulcerative colitis: usually 1–2 g four times daily initially, then 2 g daily. Arthritis: usually increased gradually to 2 g daily.
Usual dose in children
Juvenile arthritis: usually increased gradually to 30–50 mg/kg daily in two doses; maximum 2 g daily.
Common side effects
- Nausea, vomiting, loss of appetite
- Headache or dizziness
- Rash or increased sensitivity to sunlight
- Orange-yellow discoloration of urine or skin
Important warnings
- Rare serious blood, liver, kidney, or skin reactions can occur.
- Blood counts, liver function, and kidney function need monitoring.
- Drink adequate fluids; kidney stones and reduced urine output are possible.
- Avoid with sulfonamide or salicylate allergy; tell clinicians about G6PD deficiency.
Pregnancy
May be used when clinically necessary. It can reduce folate absorption; folic acid supplementation is generally recommended, especially before conception and during pregnancy.
Breastfeeding
Usually compatible, but seek medical guidance for premature or jaundiced infants, or infants with G6PD deficiency.
Interactions
- Folic acid absorption may be reduced.
- May increase bleeding risk with warfarin.
- Can reduce absorption of digoxin.
- May affect levels of some seizure medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.