About sulfadiazine
Sulfonamide antibiotic
Used for
- Treats certain bacterial infections, including toxoplasmosis with other medicines.
- Used for urinary infections and some other infections when susceptible.
Usual adult dose
Commonly 2–4 g daily in divided doses; varies by infection and combination treatment.
Usual dose in children
Usually 100–150 mg/kg daily in divided doses; specialist-directed, with age-related restrictions.
Common side effects
- Nausea, vomiting, or diarrhea
- Rash and sun sensitivity
- Blood-cell disorders
- Crystals in urine or kidney injury
Important warnings
- Serious allergic or skin reactions can occur.
- Avoid in infants younger than two months and near term in pregnancy.
- Use caution with kidney or liver disease and blood disorders.
- Adequate fluids help reduce risk of urinary crystals.
Pregnancy
Generally avoided, especially near delivery; use only when a clinician determines benefits outweigh risks.
Breastfeeding
May pass into breast milk; avoid when nursing premature, jaundiced, ill, or very young infants.
Interactions
- Warfarin: increased bleeding risk
- Methotrexate: increased toxicity
- Phenytoin: increased drug levels
- Diabetes medicines such as sulfonylureas: increased low blood sugar risk
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.