About spesolimab
Interleukin-36 receptor antagonist monoclonal antibody
Used for
- Treats generalized pustular psoriasis flares in adults and adolescents.
Usual adult dose
900 mg by intravenous infusion; a second dose may be given one week later if symptoms persist.
Usual dose in children
Adults and adolescents aged 12 years or older weighing at least 40 kg: 900 mg by intravenous infusion; repeat once after one week if needed.
Common side effects
- Infections
- Nausea
- Itching
- Injection-related reactions
Important warnings
- Can increase infection risk; assess for active infections before treatment.
- Avoid live vaccines during treatment and for 16 weeks afterward.
- Infusion reactions, including allergic reactions, can occur.
- Treatment should be given by a healthcare professional.
Pregnancy
Human pregnancy data are limited; use only when clearly needed after considering potential risks.
Breastfeeding
It is not known whether spesolimab passes into breast milk; consider treatment benefits and infant risks.
Interactions
- Avoid live vaccines during treatment and for 16 weeks afterward.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.