About sorafenib
Multikinase inhibitor
Used for
- Treats advanced kidney cancer
- Treats unresectable liver cancer
- Treats locally advanced or metastatic thyroid cancer that no longer responds to radioactive iodine
Usual adult dose
Usually 400 mg by mouth twice daily, taken without food; dose may be reduced for side effects.
Common side effects
- Diarrhea, nausea, or vomiting
- Hand-foot skin reaction or rash
- High blood pressure
- Fatigue or abdominal pain
Important warnings
- Can cause serious bleeding, heart problems, or liver injury.
- May impair wound healing; treatment is usually paused before major surgery.
- Monitor blood pressure, liver tests, and skin reactions.
- Can harm an unborn baby; effective contraception is needed during treatment.
Pregnancy
Can cause fetal harm. Avoid during pregnancy; effective contraception is needed during treatment and for 6 months after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment and for 2 weeks after the last dose.
Interactions
- Strong CYP3A4 inducers, such as rifampin, may reduce sorafenib levels.
- Warfarin may increase bleeding risk; monitor blood clotting.
- Neomycin may reduce sorafenib absorption.
- Some chemotherapy medicines can increase toxicity or affect heart rhythm.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.