About sofrafenib tosylate
Multikinase inhibitor anticancer medicine
Used for
- Advanced liver cancer
- Advanced kidney cancer
- Differentiated thyroid cancer resistant to radioactive iodine
Usual adult dose
Sorafenib: usually 400 mg twice daily, without food, at least one hour before or two hours after eating.
Common side effects
- Diarrhea, nausea, and reduced appetite
- Painful redness or peeling of hands and feet
- Tiredness and weight loss
- Rash and hair thinning
Important warnings
- Can cause severe bleeding and impaired wound healing
- May raise blood pressure or cause heart problems
- Can cause serious liver injury
- Rarely causes bowel perforation or severe skin reactions
Pregnancy
Can harm an unborn baby. Effective contraception is required during treatment and afterward: six months for women, three months for men.
Breastfeeding
Breastfeeding is not recommended during treatment or for two weeks after the last dose.
Interactions
- Rifampicin, carbamazepine, and phenytoin can reduce sorafenib effectiveness
- St John's wort can reduce sorafenib effectiveness
- Warfarin may increase bleeding risk
- Neomycin can reduce sorafenib absorption
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.