About sofosbuvir + velpatasvir + voxilaprevir
Direct-acting antiviral combination
Used for
- Treats chronic hepatitis C in adults, including some previously treated patients.
Usual adult dose
One tablet once daily with food for 12 weeks; duration may vary by clinical circumstances.
Common side effects
- Headache
- Fatigue
- Diarrhea
- Nausea
Important warnings
- Screen for hepatitis B before treatment; reactivation can occur.
- Not recommended with moderate or severe liver impairment or prior liver decompensation.
- Avoid with rifampin; it can reduce treatment effectiveness.
- Monitor for slow heart rate with amiodarone, especially alongside beta blockers.
Pregnancy
Human pregnancy data are limited; use only when benefits justify potential risks.
Breastfeeding
It is unknown whether these medicines pass into breast milk; effects on nursing infants are uncertain.
Interactions
- Avoid rifampin and other strong enzyme inducers, which can reduce drug levels.
- Amiodarone may cause serious slow heartbeat; avoid combination when possible.
- Acid-reducing medicines can lower velpatasvir levels; separate or limit use.
- Some statins may reach higher levels, increasing muscle injury risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.