About sodium valproate
Antiepileptic; mood stabiliser
Used for
- Treats epilepsy and prevents seizures.
- Treats manic episodes in bipolar disorder.
- Prevents migraine in some countries.
Usual adult dose
Epilepsy: usually 600 mg daily initially, adjusted gradually. Bipolar mania: commonly 750 mg daily initially, adjusted to response.
Usual dose in children
Epilepsy: usually 10–15 mg/kg daily initially, increased gradually under specialist supervision.
Common side effects
- Nausea, stomach discomfort, or diarrhoea
- Tremor, sleepiness, or dizziness
- Weight gain or hair thinning
- Low blood platelets or liver problems
Important warnings
- Can cause serious liver or pancreas damage; risk is higher in young children.
- Can cause birth defects and developmental harm; pregnancy risks are substantial.
- Do not stop suddenly; seizures may worsen.
- Regular blood tests may be needed to monitor liver function and blood counts.
Pregnancy
High risk of serious birth defects and developmental problems. Avoid for migraine prevention during pregnancy; epilepsy or bipolar treatment requires specialist review.
Breastfeeding
Small amounts pass into breast milk. Breastfeeding is often possible, but monitor the baby for unusual sleepiness, poor feeding, or jaundice.
Interactions
- Other seizure medicines may alter levels or increase side effects.
- Carbapenem antibiotics can sharply lower valproate levels.
- Warfarin and other blood thinners may increase bleeding risk.
- Topiramate may increase the risk of high ammonia or low body temperature.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.