About sodium valproate
Anticonvulsant and mood stabilizer
Used for
- Treats epilepsy and helps prevent seizures.
- May be used for bipolar disorder, depending on the product and country.
Usual adult dose
Epilepsy: usually 600 mg daily initially, adjusted gradually to seizure control; doses are individualized.
Usual dose in children
Epilepsy: usually 10–15 mg/kg daily initially, increased gradually; doses are individualized.
Common side effects
- Nausea, stomach discomfort, or diarrhea
- Sleepiness, tremor, or dizziness
- Weight gain
- Hair thinning or changes
Important warnings
- Can cause severe liver injury, especially in young children or with certain conditions.
- Can cause pancreatitis; seek urgent assessment for severe, persistent abdominal pain.
- Do not stop suddenly, as seizures may worsen.
- May cause suicidal thoughts or behavior in some people.
Pregnancy
Can cause major birth defects and developmental problems. Generally avoided in pregnancy unless no suitable alternative; specialist oversight is essential.
Breastfeeding
Often compatible with breastfeeding, but the infant should be monitored for unusual sleepiness, poor feeding, or jaundice.
Interactions
- Other seizure medicines may change valproate levels or increase side effects.
- Aspirin can increase valproate levels.
- Carbapenem antibiotics can sharply lower valproate levels.
- Valproate can increase lamotrigine levels and serious rash risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.