About sirolimus
mTOR inhibitor immunosuppressant
Used for
- Prevention of organ rejection after kidney transplantation
- Treatment of lymphangioleiomyomatosis
Usual adult dose
Kidney transplant: usually a loading dose, then once daily, adjusted using blood tests. Lymphangioleiomyomatosis: usually 2 mg once daily.
Usual dose in children
Kidney transplant: used in children aged 13 years and older; dosing is individualized by body size and blood levels.
Common side effects
- Mouth sores, diarrhea, nausea, or abdominal pain
- Swelling, high blood pressure, or increased cholesterol and triglycerides
- Anemia or low blood cell counts
- Infections and delayed wound healing
Important warnings
- Increases risk of serious infections and some cancers, including lymphoma and skin cancer.
- Can impair wound healing and cause fluid buildup around the lungs.
- Requires regular blood tests; blood levels and kidney function need monitoring.
- Avoid live vaccines and grapefruit; do not stop transplant medicines without medical supervision.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 12 weeks after stopping.
Breastfeeding
Breastfeeding is not recommended during treatment and for 2 weeks after the last dose.
Interactions
- Strong CYP3A4/P-glycoprotein inhibitors or inducers can greatly change sirolimus levels.
- Grapefruit may increase sirolimus levels.
- Other medicines that suppress immunity can increase infection risk.
- ACE inhibitors may increase the risk of swelling of the lips, tongue, or face.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.