About sirolimus
mTOR inhibitor immunosuppressant
Used for
- Prevention of kidney transplant rejection, usually with other medicines.
- Treatment of lymphangioleiomyomatosis (LAM).
Usual adult dose
Kidney transplant: specialist-guided loading dose, then usually 2 mg once daily. LAM: 2 mg once daily; adjust to blood levels.
Usual dose in children
Kidney transplant: specialist-guided dosing based on body size and blood levels. Not routinely used for LAM in children.
Common side effects
- Mouth sores, diarrhea, nausea, or abdominal pain.
- Swelling, high blood pressure, or raised cholesterol and triglycerides.
- Low blood-cell counts or increased infection risk.
- Delayed wound healing or lung inflammation.
Important warnings
- Requires regular blood tests and specialist monitoring.
- Increases risk of serious infections and some cancers.
- May impair wound healing; discuss planned surgery with the transplant team.
- Avoid grapefruit and grapefruit juice.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 12 weeks after stopping.
Breastfeeding
Breastfeeding is not recommended during treatment because effects on the infant are uncertain.
Interactions
- Strong CYP3A4 or P-glycoprotein inhibitors, such as clarithromycin, can raise levels.
- Strong CYP3A4 or P-glycoprotein inducers, such as rifampin, can lower levels.
- Live vaccines may be less effective or cause infection.
- Other medicines that suppress immunity can increase infection risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.