About siponimod
Sphingosine-1-phosphate receptor modulator
Used for
- Treats relapsing forms of multiple sclerosis in adults, including active secondary progressive disease.
Usual adult dose
Gradually increased over five days, then usually 2 mg once daily; some people need 1 mg daily.
Common side effects
- Headache
- High blood pressure
- Slow heart rate
- Increased liver enzymes
Important warnings
- Requires genetic testing to guide dosing and identify poor metabolizers.
- Can lower heart rate and increase infection risk.
- May cause macular swelling or liver injury; monitoring is needed.
- Stopping treatment can cause severe worsening of multiple sclerosis.
Pregnancy
May harm an unborn baby; effective contraception is recommended during treatment and for 10 days afterward.
Breastfeeding
Human data are limited; breastfeeding is generally not recommended during treatment and for 10 days afterward.
Interactions
- Avoid live vaccines during treatment and for four weeks afterward.
- Other immune-suppressing medicines can increase infection risk.
- Heart-rate-lowering medicines may increase slow-heartbeat risk.
- Strong CYP2C9 or CYP3A4 medicines can alter siponimod levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.