About ezetimibe + simvastatin
Cholesterol-lowering combination
Used for
- Treats high cholesterol alongside diet and lifestyle measures.
- May reduce risk of cardiovascular events in some people with heart disease.
Usual adult dose
One tablet once daily, usually in the evening; dose is selected according to cholesterol response and safety.
Usual dose in children
For familial hypercholesterolaemia in ages 10–17: one tablet once daily; specialist supervision is needed.
Common side effects
- Muscle aches or weakness
- Diarrhoea or abdominal discomfort
- Headache
- Raised liver enzymes
Important warnings
- Rarely causes serious muscle injury or liver problems.
- Report unexplained muscle pain, tenderness, or weakness promptly.
- Avoid during pregnancy; stop if pregnancy occurs.
- Liver disease and some medicines may make treatment unsafe.
Pregnancy
Not recommended during pregnancy because simvastatin may harm fetal development; treatment should be stopped if pregnancy occurs.
Breastfeeding
Breastfeeding is generally not recommended during treatment because simvastatin may pass into breast milk.
Interactions
- Some antibiotics and antifungals can dangerously raise simvastatin levels.
- Avoid grapefruit and grapefruit juice.
- Cyclosporine, gemfibrozil, and danazol increase muscle-injury risk.
- Warfarin may require closer monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.