About simeprevir
Direct-acting hepatitis C antiviral
Used for
- Used with other medicines to treat chronic hepatitis C infection; no longer commonly prescribed.
Usual adult dose
150 mg by mouth once daily with food, usually for 12 weeks, with other hepatitis C medicines.
Common side effects
- Rash and itching
- Nausea
- Sun sensitivity
- Raised bilirubin or jaundice
Important warnings
- Must be combined with other hepatitis C medicines.
- May cause severe skin reactions or sun sensitivity.
- Not effective against hepatitis C genotype 1a with certain resistance mutations.
- Liver disease can affect treatment choice and monitoring.
Pregnancy
Use with ribavirin is unsafe in pregnancy. Safety with other combinations is not established.
Breastfeeding
Unknown whether simeprevir passes into breast milk; combination medicines may carry additional risks.
Interactions
- Many medicines interact, including rifampin, carbamazepine, and St John’s wort.
- Some HIV medicines and transplant medicines can interact.
- Check all medicines and supplements before use.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.