About sertraline
Selective serotonin reuptake inhibitor antidepressant
Used for
- Depression
- Obsessive-compulsive disorder
- Panic disorder and social anxiety disorder
- Post-traumatic stress disorder and premenstrual dysphoric disorder
Usual adult dose
Usually 50 mg once daily for depression or obsessive-compulsive disorder; other conditions often start at 25 mg daily. Doses may be adjusted up to 200 mg daily.
Usual dose in children
For obsessive-compulsive disorder: ages 6–12, usually 25 mg once daily; ages 13–17, usually 50 mg once daily. Clinician-guided adjustments may follow.
Common side effects
- Nausea, diarrhea, or indigestion
- Headache, dizziness, or tremor
- Sleep changes or fatigue
- Sexual problems or increased sweating
Important warnings
- May increase suicidal thoughts or behavior, especially in young people early in treatment.
- Do not stop suddenly; withdrawal symptoms can occur.
- Can cause serotonin syndrome, particularly with other serotonin-raising medicines.
- May trigger mania, increase bleeding risk, or cause low blood sodium.
Pregnancy
Use only after weighing benefits and risks; late-pregnancy exposure may affect newborn adaptation. Untreated illness also carries risks.
Breastfeeding
Sertraline enters breast milk in small amounts and is often considered compatible; monitor infants for unusual sleepiness or feeding problems.
Interactions
- MAO inhibitors and linezolid: risk of serotonin syndrome; combination is generally avoided.
- Other serotonergic medicines, including tramadol and triptans, can increase serotonin syndrome risk.
- NSAIDs, aspirin, and blood thinners can increase bleeding risk.
- Pimozide is contraindicated; medicines affecting sertraline levels may require review.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.