About sepiapterin
Tetrahydrobiopterin synthesis enhancer
Used for
- Treats phenylketonuria (PKU) in people with responsive disease.
- Treats sepiapterin reductase deficiency and associated neurotransmitter disorders.
Usual adult dose
PKU: typically 20 mg/kg by mouth once daily; specialists adjust according to blood phenylalanine levels.
Usual dose in children
PKU: typically 20 mg/kg by mouth once daily; specialists adjust according to blood phenylalanine levels. Sepiapterin reductase deficiency dosing is specialist-directed.
Common side effects
- Headache
- Diarrhea
- Abdominal pain
- Nausea
Important warnings
- Use with a low-phenylalanine diet for PKU, as prescribed.
- Monitor blood phenylalanine and nutritional status during treatment.
- May lower blood phenylalanine excessively; dose changes may be needed.
- Not all people with PKU respond to treatment.
Pregnancy
Human pregnancy data are limited. Use requires specialist assessment of benefits and risks; maintaining PKU control during pregnancy is important.
Breastfeeding
There are limited data on use during breastfeeding; specialist assessment is appropriate.
Interactions
- Levodopa may increase effects such as abnormal movements or irritability.
- Other medicines affecting phenylalanine levels may alter treatment response.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.