About selinexor
Selective nuclear export inhibitor
Used for
- Treats certain adults with multiple myeloma, usually with other cancer medicines.
- Treats certain adults with diffuse large B-cell lymphoma after prior treatments.
Usual adult dose
Multiple myeloma: usually 80 mg twice weekly with dexamethasone, or 100 mg once weekly with other medicines. Lymphoma: usually 60 mg twice weekly. Doses may be adjusted.
Common side effects
- Low platelet, red blood cell, or white blood cell counts
- Nausea, vomiting, diarrhea, constipation, or reduced appetite
- Tiredness, weakness, or weight loss
- Low sodium, dizziness, or confusion
Important warnings
- Can cause serious low blood counts, infections, bleeding, and dehydration.
- Low sodium can cause confusion, seizures, or other serious problems.
- May cause severe nausea, vomiting, and reduced appetite; supportive medicines are commonly used.
- Requires monitoring of blood counts, sodium, hydration, and body weight.
Pregnancy
May harm an unborn baby. Pregnancy should be avoided during treatment and for five weeks after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment or for one week after the last dose.
Interactions
- Strong CYP3A4 inhibitors may increase selinexor exposure.
- Strong CYP3A4 inducers may reduce selinexor exposure.
- Medicines affecting blood clotting may increase bleeding concerns when blood counts are low.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.