About selexipag
Prostacyclin receptor agonist
Used for
- Treats pulmonary arterial hypertension to delay disease worsening and reduce hospitalization risk.
Usual adult dose
Usually starts at 200 micrograms twice daily; increase by 200 micrograms twice daily weekly as tolerated, up to 1,600 micrograms twice daily.
Common side effects
- Headache
- Diarrhea
- Nausea or vomiting
- Jaw pain
Important warnings
- Can cause low blood pressure or bleeding.
- May worsen liver problems; dose adjustment may be needed.
- Do not stop suddenly without medical supervision.
- Swallow tablets whole; do not split, crush, or chew.
Pregnancy
Human pregnancy data are limited; use only when the potential benefit justifies possible fetal risk.
Breastfeeding
It is unknown whether selexipag passes into breast milk; breastfeeding decisions require clinical consideration.
Interactions
- Gemfibrozil substantially increases selexipag exposure and should not be used together.
- Strong CYP2C8 inhibitors, such as clopidogrel, may require dose adjustment.
- Strong CYP2C8 inducers, such as rifampin, may reduce effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.