About selexipag
Prostacyclin receptor agonist
Used for
- Treats pulmonary arterial hypertension to improve exercise ability and reduce disease worsening risk.
Usual adult dose
Usually starts at 200 micrograms twice daily; increase weekly by 200 micrograms per dose as tolerated, up to 1,600 micrograms twice daily.
Usual dose in children
Not established for children under 18 years.
Common side effects
- Headache
- Diarrhea
- Nausea and vomiting
- Jaw, muscle, or limb pain
Important warnings
- Dose increases may cause side effects; adjust gradually with clinical supervision.
- Can cause low blood pressure or increase bleeding risk.
- Avoid in severe liver impairment; use caution with moderate impairment.
- Do not stop suddenly without medical guidance.
Pregnancy
Human pregnancy data are limited. Use only when clearly needed after discussing risks with a clinician.
Breastfeeding
It is unknown whether selexipag or its metabolites pass into human milk; risks to the infant are uncertain.
Interactions
- Gemfibrozil greatly increases selexipag exposure; avoid combined use.
- Strong CYP2C8 inhibitors, such as clopidogrel, may increase exposure; dose adjustment may be needed.
- Strong CYP2C8 inducers, such as rifampin, may reduce exposure.
- Other blood-pressure-lowering or bleeding-risk medicines may increase related effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.