About seladelpar lysine dihydrate
PPAR-delta agonist
Used for
- Treats primary biliary cholangitis in adults, with ursodeoxycholic acid or alone if it is not tolerated.
Usual adult dose
10 mg by mouth once daily.
Common side effects
- Headache
- Abdominal pain
- Nausea
- Abdominal swelling
Important warnings
- Not recommended for severe liver impairment or decompensated cirrhosis.
- Liver tests may worsen; monitoring is recommended.
- May cause fractures.
- Avoid strong CYP2C9 inhibitors and strong or moderate CYP2C8 inhibitors.
Pregnancy
There are limited human data; animal studies suggest possible fetal harm. Use only if benefits justify risks.
Breastfeeding
Unknown whether seladelpar passes into breast milk; effects on infants are unknown.
Interactions
- CYP2C9 inhibitors may increase seladelpar levels.
- CYP2C8 inhibitors may increase seladelpar levels.
- Bile acid sequestrants can reduce absorption; separate doses by at least four hours.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.