About sebelipase alfa
Recombinant lysosomal acid lipase
Used for
- Long-term enzyme replacement for lysosomal acid lipase deficiency, including Wolman disease and cholesteryl ester storage disease.
Usual adult dose
1 mg/kg by intravenous infusion every other week; some adults may need 3 mg/kg every other week.
Usual dose in children
Infants with rapidly progressive disease: 1 mg/kg weekly, increased to 3 mg/kg weekly if needed. Other children: 1 mg/kg every other week.
Common side effects
- Headache
- Fever
- Diarrhoea
- Infusion-related allergic reactions, including anaphylaxis
Important warnings
- Serious allergic reactions can occur during or after infusion.
- Antibodies may develop and can affect treatment response or cause reactions.
- Infusions require monitoring by healthcare professionals.
- Use caution in patients with previous severe allergic reactions to egg products.
Pregnancy
Human pregnancy data are limited; use only when the potential benefit justifies possible risk.
Breastfeeding
It is not known whether sebelipase alfa passes into breast milk; consider benefits and potential risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.