About saxagliptin + metformin hcl
DPP-4 inhibitor and biguanide combination
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually one tablet once daily with the evening meal; dose depends on prior treatment and kidney function.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal discomfort
- Headache or upper respiratory symptoms
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- Rare but serious lactic acidosis; risk rises with kidney problems or severe illness.
- Can cause pancreatitis, heart failure, or severe joint pain.
- Check kidney function before and during treatment.
- Not for type 1 diabetes or diabetic ketoacidosis.
Pregnancy
Use only when clearly needed; insulin is generally preferred for diabetes during pregnancy.
Breastfeeding
Metformin enters breast milk; saxagliptin milk-transfer data are limited. Discuss risks with a healthcare professional.
Interactions
- Strong CYP3A4/5 inhibitors, such as ketoconazole, can increase saxagliptin levels.
- Alcohol may increase lactic acidosis risk.
- Insulin or sulfonylureas can increase low blood sugar risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.