About saxaglipti n
DPP-4 inhibitor plus biguanide
Used for
- Type 2 diabetes, alongside diet and exercise.
- Improves blood sugar when either medicine alone is insufficient.
Usual adult dose
Usually one tablet once daily with the evening meal; dose depends on kidney function and prior treatment.
Common side effects
- Diarrhea, nausea, or stomach discomfort
- Headache or upper respiratory symptoms
- Low blood sugar, especially with insulin or sulfonylureas
- Rarely, pancreatitis or heart failure
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Metformin can rarely cause serious lactic acidosis; risk increases with kidney problems.
- Saxagliptin may worsen heart failure; seek prompt assessment for new swelling or breathlessness.
- Kidney function should be checked; avoid in severe kidney impairment.
Pregnancy
Use only when prescribed; diabetes treatment needs careful monitoring during pregnancy.
Breastfeeding
Metformin passes into breast milk; breastfeeding use requires clinician review because combination-product data are limited.
Interactions
- Strong CYP3A4/5 inhibitors, such as ketoconazole, can increase saxagliptin exposure.
- Insulin or sulfonylureas increase low-blood-sugar risk.
- Alcohol and medicines affecting kidney function may increase metformin-related risks.
- Iodinated contrast procedures may require temporary interruption due to metformin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.