About sacubitril + valsartan
Angiotensin receptor-neprilysin inhibitor
Used for
- Treats chronic heart failure with reduced ejection fraction in adults.
- Treats certain children with symptomatic heart failure and reduced pumping ability.
Usual adult dose
Usually twice daily; starts at 49/51 mg and is increased after 2–4 weeks toward 97/103 mg, as tolerated.
Usual dose in children
For children aged 1 year or older, dosing is weight-based twice daily and adjusted by a clinician.
Common side effects
- Low blood pressure or dizziness
- High potassium
- Kidney function changes
- Cough
Important warnings
- Do not use with an ACE inhibitor; allow 36 hours between medicines.
- Avoid during pregnancy; it can harm or kill an unborn baby.
- Risk of severe swelling of the face, lips, tongue, or throat.
- Monitor blood pressure, kidney function, and potassium.
Pregnancy
Can cause fetal injury or death, especially in later pregnancy; discontinue promptly if pregnancy occurs.
Breastfeeding
Breastfeeding is not recommended during treatment because of possible serious effects on the infant.
Interactions
- ACE inhibitors, including enalapril or lisinopril
- Aliskiren, especially in people with diabetes
- Potassium supplements or potassium-sparing diuretics
- NSAIDs, such as ibuprofen or naproxen
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.