About rivaroxaban ph eur
Direct factor Xa inhibitor anticoagulant
Used for
- Prevention of stroke and systemic embolism in non-valvular atrial fibrillation
- Treatment and prevention of deep vein thrombosis and pulmonary embolism
- Prevention of blood clots after hip or knee replacement surgery
Usual adult dose
Atrial fibrillation: 20 mg once daily with food (15 mg once daily in some kidney impairment). DVT/PE: 15 mg twice daily for 21 days, then 20 mg once daily.
Usual dose in children
For children with venous clots, dosing depends on age, weight, and treatment phase; specialist-directed dosing is required.
Common side effects
- Bleeding, including nose or gum bleeding
- Easy bruising
- Anaemia
- Nausea
Important warnings
- Bleeding can be severe or life-threatening
- Do not stop suddenly without prescriber guidance
- Dose may need adjustment for kidney or liver problems
- Spinal or epidural procedures can increase risk of spinal bleeding
Pregnancy
Generally avoided in pregnancy because of bleeding risk; anticoagulation needs specialist management.
Breastfeeding
Avoid during breastfeeding; an alternative anticoagulant is generally preferred.
Interactions
- Other anticoagulants and antiplatelet medicines increase bleeding risk
- NSAIDs such as ibuprofen can increase bleeding risk
- Some antifungals and HIV medicines can raise rivaroxaban levels
- Rifampicin, carbamazepine, and St John’s wort can reduce its effect
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.