About risdiplam
SMN2 splicing modifier
Used for
- Treatment of spinal muscular atrophy in adults and children, including infants.
Usual adult dose
Adults weighing 20 kg or more: 5 mg by mouth once daily.
Usual dose in children
Dose depends on age and weight: under 2 months, 0.15 mg/kg daily; 2 months to under 2 years, 0.2 mg/kg daily; age 2 years or older and under 20 kg, 0.25 mg/kg daily; 20 kg or more, 5 mg daily.
Common side effects
- Fever
- Diarrhea
- Rash
- Headache
Important warnings
- Use the supplied oral syringe; follow preparation and storage instructions.
- May cause fetal harm based on animal studies; discuss pregnancy prevention.
- May impair male fertility based on animal studies.
- Tell clinicians about all medicines, including supplements.
Pregnancy
May cause fetal harm based on animal studies. Human pregnancy data are limited.
Breastfeeding
It is unknown whether risdiplam passes into human milk; effects on infants are unknown.
Interactions
- Avoid coadministration with metformin when possible; risdiplam may increase metformin exposure.
- Other medicines that affect MATE transporters may alter risdiplam or their own exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.