About rilpivirine
Non-nucleoside reverse transcriptase inhibitor
Used for
- Treats HIV-1 infection with other antiretroviral medicines.
Usual adult dose
25 mg by mouth once daily with a meal, alongside other HIV medicines.
Usual dose in children
For children aged 2 years and older weighing at least 14 kg, dose is weight-based once daily with a meal.
Common side effects
- Depression or mood changes
- Headache
- Difficulty sleeping
- Rash
Important warnings
- Not suitable for untreated HIV viral loads above 100,000 copies/mL or certain resistance patterns.
- May cause depression or suicidal thoughts.
- Stopping or missing doses can lead to HIV drug resistance.
- Acid-reducing medicines can lower rilpivirine levels and reduce effectiveness.
Pregnancy
Use during pregnancy only when the benefits outweigh risks; HIV specialist monitoring is important.
Breastfeeding
Breastfeeding is not recommended with HIV infection in settings where safe alternatives are available.
Interactions
- Proton pump inhibitors are contraindicated.
- Rifampin, rifabutin, and St John’s wort can reduce levels.
- Separate antacids by at least 2 hours before or 4 hours after.
- Some seizure medicines and dexamethasone can reduce effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.