About rilonacept
Interleukin-1 inhibitor
Used for
- Cryopyrin-associated periodic syndromes, including familial cold autoinflammatory syndrome and Muckle-Wells syndrome
- Recurrent pericarditis and prevention of recurrence
Usual adult dose
Periodic syndromes: 320 mg once, then 160 mg weekly. Recurrent pericarditis: 320 mg once, then 160 mg weekly.
Usual dose in children
Periodic syndromes, ages 12 and older: 4.4 mg/kg (maximum 320 mg) once, then 2.2 mg/kg (maximum 160 mg) weekly.
Common side effects
- Injection-site reactions
- Upper respiratory infections
- Headache
- Raised cholesterol or triglycerides
Important warnings
- Serious infections can occur; treatment should not start during an active infection.
- Avoid live vaccines during treatment.
- May increase cholesterol and triglycerides.
- Discuss tuberculosis screening and infection risks before treatment.
Pregnancy
Human pregnancy data are limited; use only when the potential benefit justifies potential risk.
Breastfeeding
It is not known whether rilonacept enters human milk; consider benefits and potential risks.
Interactions
- Avoid live vaccines during treatment.
- Other biologic medicines that suppress the immune system may increase infection risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.