About rifampin
Rifamycin antibiotic
Used for
- Treats tuberculosis, usually with other medicines.
- Treats serious infections caused by susceptible bacteria, under specialist supervision.
Usual adult dose
Tuberculosis: usually 10 mg/kg once daily, maximum 600 mg. IV dosing is generally similar and depends on clinical circumstances.
Usual dose in children
Tuberculosis: usually 10–20 mg/kg once daily, maximum 600 mg; specialist dosing is required.
Common side effects
- Orange-red discoloration of urine, sweat, tears, or other body fluids
- Nausea, vomiting, or abdominal discomfort
- Liver inflammation or abnormal liver tests
- Flu-like symptoms or rash
Important warnings
- Can cause serious liver injury; liver monitoring may be needed.
- Do not use alone to treat tuberculosis; resistance can develop.
- May reduce the effectiveness of many medicines, including hormonal contraceptives.
- Intravenous use can cause severe allergic reactions or infusion-related problems.
Pregnancy
May be used for tuberculosis when needed; treatment requires clinician assessment. It can increase bleeding risk near delivery.
Breastfeeding
Generally compatible when clinically indicated; small amounts enter breast milk and may discolor it.
Interactions
- Strongly lowers levels of many medicines, including warfarin, some HIV drugs, antifungals, and transplant medicines.
- Can reduce hormonal contraceptive effectiveness; use a non-hormonal method during treatment.
- Antacids can reduce absorption of oral rifampicin; separate administration.
- May increase liver-injury risk with other liver-toxic medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.