About ribociclib
Cyclin-dependent kinase 4/6 inhibitor
Used for
- Used with hormone therapy for certain hormone receptor-positive, HER2-negative advanced breast cancers.
- Used with an aromatase inhibitor for some early, high-risk breast cancers.
Usual adult dose
Usually 600 mg once daily for 21 days, then 7 days off; dose and schedule depend on treatment setting.
Common side effects
- Low white blood cell counts
- Nausea, diarrhea, or constipation
- Fatigue
- Abnormal liver tests
Important warnings
- Can cause serious heart rhythm changes; ECG and electrolyte monitoring are required.
- Can cause severe liver problems and low blood counts; regular blood tests are needed.
- Avoid grapefruit and strong CYP3A inhibitors or inducers.
- May harm an unborn baby; effective contraception is required during treatment and for 3 weeks afterward.
Pregnancy
Can cause fetal harm; avoid during pregnancy. Use effective contraception during treatment and for 3 weeks after the last dose.
Breastfeeding
Do not breastfeed during treatment and for 3 weeks after the last dose.
Interactions
- Strong CYP3A inhibitors can increase ribociclib levels and side effects.
- Strong CYP3A inducers can reduce its effectiveness.
- Ribociclib can increase levels of some medicines, including certain statins and QT-prolonging drugs.
- Grapefruit may increase ribociclib levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.