About ranolazine
Anti-anginal; late sodium-current inhibitor
Used for
- Treats chronic angina (chest pain) in adults, usually alongside other medicines.
Usual adult dose
Usually 500 mg twice daily; may increase to 1,000 mg twice daily if needed and tolerated.
Common side effects
- Constipation
- Dizziness
- Headache
- Nausea
Important warnings
- Not for sudden chest pain or heart attacks.
- May prolong the heart’s QT interval, increasing risk of abnormal heart rhythms.
- Avoid with severe liver disease.
- Swallow tablets whole; do not crush, break, or chew.
Pregnancy
Limited information; use only when a clinician considers it necessary.
Breastfeeding
Unknown whether ranolazine passes into breast milk; discuss risks with a clinician.
Interactions
- Avoid strong CYP3A inhibitors, such as clarithromycin and ketoconazole.
- Avoid strong CYP3A inducers, such as rifampin and carbamazepine.
- Can increase levels of simvastatin, digoxin, and some other medicines.
- Other QT-prolonging medicines may increase abnormal heart rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.