About ranolazine
Anti-anginal medicine
Used for
- Treats chronic angina (chest pain) in adults, usually alongside other treatments.
Usual adult dose
Usually 375 mg twice daily initially; increased gradually if needed, up to 750 mg twice daily.
Common side effects
- Dizziness or headache
- Constipation, nausea, or vomiting
- Weakness
Important warnings
- Can prolong the heart’s electrical QT interval and rarely cause abnormal rhythms.
- Avoid in severe liver disease; use caution with kidney problems.
- Do not use with strong CYP3A inhibitors or inducers.
- Swallow prolonged-release tablets whole; do not crush or chew.
Pregnancy
Use during pregnancy only when clearly necessary; human safety information is limited.
Breastfeeding
Breastfeeding safety is unclear; use requires consideration of potential infant risk.
Interactions
- Strong CYP3A inhibitors, such as clarithromycin, can raise ranolazine levels.
- Strong CYP3A inducers, such as rifampicin, can reduce its effect.
- May increase levels of digoxin, simvastatin, and some other medicines.
- Other QT-prolonging medicines may increase abnormal heart-rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.