About radamts
Recombinant ADAMTS13 enzyme replacement
Used for
- Prevention and treatment of thrombotic thrombocytopenic purpura (TTP) in adults and children with congenital TTP.
Usual adult dose
Prophylaxis: 40 IU/kg intravenously once weekly; adjust to every other week based on response. On-demand treatment: 40 IU/kg on day 1, 20 IU/kg on day 2, then 15 IU/kg daily until two days after symptoms resolve.
Usual dose in children
Same weight-based dosing as adults; dosing intervals may be adjusted according to clinical response.
Common side effects
- Headache
- Diarrhea
- Nausea
- Dizziness
Important warnings
- Severe allergic reactions, including anaphylaxis, may occur.
- Monitor for neutralizing antibodies that reduce treatment effect.
- Not indicated for acquired TTP.
- Treatment requires intravenous administration and specialist monitoring.
Pregnancy
Human pregnancy data are limited; use only when clearly needed and potential benefit outweighs risk.
Breastfeeding
It is unknown whether the medicine passes into breast milk; consider benefits and potential risks.
Interactions
- No clinically significant drug interactions are established.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.