About r l asparaginase
Antineoplastic enzyme
Used for
- Treatment of acute lymphoblastic leukemia as part of combination chemotherapy.
Usual adult dose
Dose is individualized by body-surface area and treatment protocol; commonly 5,000–10,000 IU/m² intravenously per dose.
Usual dose in children
Dose is individualized by body-surface area and treatment protocol; commonly 5,000–10,000 IU/m² intravenously per dose.
Common side effects
- Allergic reactions, including severe hypersensitivity
- Pancreatitis
- Liver problems
- Blood clots or bleeding
Important warnings
- Must be given under specialist supervision with monitoring.
- Can cause severe allergic reactions, pancreatitis, liver injury, or abnormal blood clotting.
- Treatment may require monitoring of blood counts, liver function, glucose, and clotting.
Pregnancy
May harm an unborn baby; pregnancy should be avoided during treatment and for the period specified by the treatment team.
Breastfeeding
Breastfeeding is not recommended during treatment.
Interactions
- Other chemotherapy medicines can increase toxicity or alter treatment effects.
- Vaccines may be less effective during chemotherapy; live vaccines may be unsafe.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.