About meclozine dihydrochloride + pyridoxine hydrochloride
Antihistamine and vitamin B6 combination
Used for
- Prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness.
- Treatment of nausea and vomiting during pregnancy in some countries.
Usual adult dose
Motion sickness: meclozine 25–50 mg about one hour before travel; repeat every 24 hours if needed. Combination-product directions vary.
Usual dose in children
For motion sickness, meclozine is generally used only from age 12: 25–50 mg before travel, then once daily if needed. Combination-product directions vary.
Common side effects
- Sleepiness or tiredness
- Dry mouth
- Blurred vision
- Constipation
Important warnings
- May impair driving and coordination; avoid alcohol and sedatives.
- Use caution with glaucoma, enlarged prostate, or difficulty urinating.
- Long-term high-dose vitamin B6 can cause nerve damage.
- Combination dosing and approved uses vary by country.
Pregnancy
Meclozine and pyridoxine are used for pregnancy-related nausea in some countries; local guidance and product labeling differ.
Breastfeeding
Meclozine may cause infant drowsiness or reduce milk supply; pyridoxine is generally compatible with breastfeeding.
Interactions
- Alcohol, opioids, sleeping medicines, and other sedatives can increase drowsiness.
- Other medicines with anticholinergic effects can worsen dry mouth, blurred vision, or urinary difficulty.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.