About prucalopride succinate
Selective serotonin-4 receptor agonist
Used for
- Treats chronic constipation when laxatives have not worked well enough.
Usual adult dose
Usually 2 mg by mouth once daily; 1 mg daily may be used with severe kidney impairment or in some older adults.
Common side effects
- Headache
- Nausea
- Diarrhea
- Abdominal pain
Important warnings
- Seek urgent help for severe or persistent abdominal pain, vomiting, or bowel blockage symptoms.
- Mood changes and suicidal thoughts have been reported; monitor for new or worsening symptoms.
- Avoid with bowel perforation or obstruction, severe inflammatory bowel disease, or toxic megacolon.
Pregnancy
Limited information is available; use during pregnancy is generally avoided unless a clinician considers it necessary.
Breastfeeding
Small amounts may pass into breast milk; use requires clinician guidance.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, may increase prucalopride exposure.
- Prucalopride may increase blood levels of digoxin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.