About prucalopri de
Selective serotonin-4 receptor agonist
Used for
- Treats chronic constipation in adults when laxatives have not worked adequately.
Usual adult dose
Usually 2 mg once daily; 1 mg once daily for older adults or severe kidney problems.
Common side effects
- Headache
- Abdominal pain
- Nausea
- Diarrhoea
Important warnings
- Avoid with intestinal obstruction, perforation, or severe inflammatory bowel disease.
- Use caution with severe kidney or liver impairment.
- Stop and seek medical advice for severe or persistent diarrhoea.
- Mood changes and suicidal thoughts have been reported; monitor for these symptoms.
Pregnancy
Generally avoid during pregnancy; human pregnancy data are limited.
Breastfeeding
Not recommended during breastfeeding because transfer into breast milk is possible.
Interactions
- Strong CYP3A4 inhibitors may increase prucalopride exposure.
- Medicines that prolong the QT interval may increase heart-rhythm risks.
- Prucalopride may increase absorption of oral medicines, including digoxin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.