About prothrombin
Four-factor prothrombin complex concentrate
Used for
- Rapid reversal of vitamin K antagonist anticoagulants, such as warfarin, during serious bleeding or urgent surgery.
- Treatment of certain acquired clotting factor deficiencies when specific products are unavailable.
Usual adult dose
For urgent warfarin reversal, dose by body weight and INR: commonly 25–50 IU/kg intravenously, with a maximum of 5,000 IU; follow product-specific guidance.
Common side effects
- Blood clots, including stroke, heart attack, or deep-vein thrombosis.
- Allergic reactions, including severe hypersensitivity.
- Headache, nausea, or fever.
Important warnings
- Can cause life-threatening blood clots; use only when rapid clotting-factor replacement is needed.
- Vitamin K is usually given alongside it for warfarin reversal.
- Contains heparin; contraindicated in heparin-induced thrombocytopenia.
- Dosing and monitoring require trained medical professionals.
Pregnancy
Use only when clearly necessary; pregnancy data are limited, and clotting risks require careful assessment.
Breastfeeding
Information is limited; use requires clinical assessment of maternal need and potential risks.
Interactions
- Vitamin K supports sustained reversal of warfarin; it is commonly administered with this medicine.
- Other clot-promoting medicines may increase the risk of blood clots.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.