About progesterone
Natural progesterone hormone
Used for
- Supports the luteal phase in assisted reproduction treatment
- Treats premenstrual syndrome
- Treats postpartum depression in some countries
- Treats threatened or recurrent miscarriage in selected circumstances
Usual adult dose
Assisted reproduction: usually 400 mg vaginally twice daily. Other uses and regimens vary by country and indication.
Common side effects
- Sleepiness or dizziness
- Breast tenderness or pain
- Abdominal discomfort or bloating
- Vaginal discharge or irritation
Important warnings
- May cause drowsiness; avoid driving if affected.
- Not suitable for unexplained vaginal bleeding or severe liver disease.
- Seek urgent care for chest pain, breathlessness, or one-sided leg swelling.
- Use only for the prescribed indication; pregnancy-related recommendations vary.
Pregnancy
Used in selected pregnancies, including assisted reproduction; benefits and duration depend on the indication and local guidance.
Breastfeeding
Progesterone enters breast milk in small amounts; discuss use with a healthcare professional.
Interactions
- Enzyme-inducing medicines, such as carbamazepine or rifampicin, may reduce progesterone effects.
- Some antifungal medicines and other enzyme inhibitors may alter progesterone levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.