About pretomanid
Nitroimidazooxazine antimycobacterial
Used for
- Used with bedaquiline and linezolid to treat certain forms of drug-resistant tuberculosis in adults.
Usual adult dose
200 mg by mouth once daily with food for 26 weeks, as part of the combination regimen.
Common side effects
- Nausea, vomiting, and abdominal pain
- Headache
- Liver enzyme abnormalities
- Low blood cell counts, especially with linezolid
Important warnings
- Use only with the prescribed combination medicines and specialist supervision.
- Can cause liver injury; monitoring is required.
- Combination treatment can cause nerve damage and low blood counts.
- Treatment duration and eligibility depend on the specific tuberculosis regimen.
Pregnancy
Human pregnancy data are limited; use requires careful assessment of treatment benefits and potential fetal risks.
Breastfeeding
It is unknown whether pretomanid enters human milk; assess risks and benefits with a clinician.
Interactions
- Pretomanid may interact with medicines affecting drug-metabolizing enzymes, including some HIV treatments.
- Rifampin and other strong enzyme inducers may lower pretomanid levels.
- Check all medicines for interactions with the full bedaquiline-linezolid-pretomanid regimen.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.