About pramipexole dihydrochloride monohydrate
Dopamine agonist
Used for
- Parkinson’s disease
- Restless legs syndrome (immediate-release formulations; not prolonged-release tablets)
Usual adult dose
Parkinson’s disease: usually starts at 0.375 mg once daily, increased gradually as needed. Swallow prolonged-release tablets whole.
Common side effects
- Nausea
- Dizziness or sleepiness
- Low blood pressure when standing
- Hallucinations or abnormal movements
Important warnings
- May cause sudden sleep episodes; avoid driving if affected.
- Can cause compulsive gambling, shopping, eating, or sexual behavior.
- Do not stop abruptly; dose reduction should be gradual.
- Kidney impairment may require a lower dose or slower increases.
Pregnancy
Use in pregnancy is generally avoided unless clearly needed; human safety information is limited.
Breastfeeding
May reduce milk production and may enter breast milk; breastfeeding use is generally not recommended.
Interactions
- Dopamine-blocking medicines, including some antipsychotics, may reduce its effect.
- Sedatives and alcohol can worsen sleepiness.
- Cimetidine and other medicines affecting kidney elimination may increase pramipexole levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.