About posaconazole
Triazole antifungal
Used for
- Prevention of invasive fungal infections in people with severely weakened immunity
- Treatment of certain invasive Aspergillus infections when other treatments fail or cannot be used
Usual adult dose
Usually 300 mg twice on day one, then 300 mg once daily; treatment duration depends on infection.
Usual dose in children
For children aged 2 years and older, dosing is weight-based and specialist-directed; this tablet is unsuitable below 40 kg.
Common side effects
- Nausea, vomiting, or diarrhea
- Headache
- Liver enzyme changes
- Low potassium levels
Important warnings
- Can cause serious liver problems; monitoring may be needed.
- May affect heart rhythm, especially with low potassium or magnesium.
- Swallow tablets whole; do not crush, split, or chew.
- Tablets and oral suspension are not interchangeable.
Pregnancy
Avoid during pregnancy unless clearly needed; human safety information is limited.
Breastfeeding
It is not known whether posaconazole passes into breast milk; discuss risks with a clinician.
Interactions
- Can dangerously increase levels of some medicines, including certain statins and ergot medicines.
- Rifampin, rifabutin, phenytoin, and some other drugs can lower posaconazole levels.
- May increase tacrolimus or cyclosporine levels; monitoring and dose adjustment may be needed.
- Can interact with medicines that prolong the heart rhythm.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.