About ponesimod
Sphingosine-1-phosphate receptor modulator
Used for
- Treats relapsing forms of multiple sclerosis in adults.
Usual adult dose
Once daily: gradually increase from 2 mg to 10 mg over 14 days, then 20 mg daily.
Common side effects
- Upper respiratory infections
- Headache
- High blood pressure
- Elevated liver enzymes
Important warnings
- May slow heart rate when starting; dose titration and monitoring may be needed.
- Can increase infection risk; screening for certain infections is required.
- May cause liver injury or macular swelling.
- Avoid live vaccines during treatment and for one to two weeks afterward.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for one week after stopping.
Breastfeeding
It is unknown whether ponesimod passes into human milk; discuss potential risks and benefits with a healthcare professional.
Interactions
- Medicines that slow heart rate or affect heart rhythm may increase cardiac risks.
- Other immune-suppressing medicines may increase infection risk.
- Strong enzyme inducers, such as rifampin, may reduce ponesimod levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.