About ponesimod
Sphingosine-1-phosphate receptor modulator
Used for
- Treats relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome.
Usual adult dose
Taken once daily using a 14-day starter pack, gradually increasing to the prescribed maintenance dose.
Common side effects
- Upper respiratory infections
- Elevated liver enzymes
- High blood pressure
- Slow heart rate, especially when starting treatment
Important warnings
- May increase infection risk; check for infections before and during treatment.
- Requires heart assessment and monitoring when starting in some people.
- Can cause liver injury and macular swelling; monitoring may be needed.
- Do not stop suddenly without medical guidance; severe worsening can occur.
Pregnancy
May harm an unborn baby. Effective contraception is advised during treatment and for one week after stopping.
Breastfeeding
It is unknown whether ponesimod passes into human milk; discuss risks and benefits with a clinician.
Interactions
- Other immune-suppressing medicines may increase infection risk.
- Medicines that slow heart rate or affect heart rhythm may interact.
- Strong CYP3A4 or UGT1A1 inhibitors or inducers can change ponesimod levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.