About plerixafor
Hematopoietic stem-cell mobilizer
Used for
- Used with filgrastim to mobilize stem cells into blood before collection for transplantation in certain blood cancers.
Usual adult dose
0.24 mg/kg under the skin once daily, usually for up to four days; given about 11 hours before collection.
Usual dose in children
0.24 mg/kg under the skin once daily, usually for up to four days; specialist dosing applies, especially with kidney impairment.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Injection-site reactions
- Dizziness, headache, or fatigue
- Low blood platelet count
Important warnings
- May cause enlarged spleen or, rarely, spleen rupture; report left upper abdominal or shoulder pain.
- Can cause severe allergic reactions, including anaphylaxis.
- Monitor blood counts; increased white blood cells and low platelets can occur.
- Dose adjustment is needed with reduced kidney function.
Pregnancy
May harm an unborn baby; pregnancy status should be checked before treatment.
Breastfeeding
Breastfeeding is not recommended during treatment and for one week after the final dose.
Interactions
- No established clinically significant drug interactions are known.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.