About pioglitazone + glimepiride
Thiazolidinedione and sulfonylurea combination
Used for
- Type 2 diabetes, alongside diet and exercise, to improve blood sugar control
Usual adult dose
Usually one tablet once daily with the first main meal; dosing is individualized by a clinician.
Common side effects
- Low blood sugar
- Weight gain
- Swelling or fluid retention
- Headache or dizziness
Important warnings
- Can cause or worsen heart failure; avoid in severe heart failure.
- Low blood sugar may be severe or prolonged, especially with missed meals.
- May increase fracture risk and cause liver problems.
- Not for type 1 diabetes or diabetic ketoacidosis.
Pregnancy
Not generally recommended during pregnancy; diabetes treatment needs clinician-directed review.
Breastfeeding
Breastfeeding safety is not established; discuss treatment with a clinician.
Interactions
- Insulin can increase fluid retention and heart failure risk.
- Other diabetes medicines can increase low blood sugar risk.
- Some medicines, including rifampin, can alter pioglitazone levels.
- Beta blockers may mask warning signs of low blood sugar.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.